ESCRT-I controls lysosomal membrane protein homeostasis and restricts MCOLN1-dependent TFEB/TFE3 signaling.
M. Wrobel, E. Szymanska, N. Budick-Harmelin, K. Kolmus, K. Goryca, M. Dabrowska, A. Paziewska, M. Mikula, J. Cendrowski, M. Miaczynska
This study shows ESCRT-I regulates lysosomal membrane protein homeostasis and modulates TFEB/TFE3 signaling through MCOLN1-dependent Ca2+ channels.
bioRxiv · Jul 26, 2021 · PreprintCell Biology