Author

N. Domingues

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Approach:experimental assay· 1 Assay:metabolomics· 1 Approach:statistical model· 1 Organism:zebrafish· 1

Frequent Co-Authors

C. Klose· 2 shared J. Ferreira· 2 shared J. Sampaio· 2 shared K. Simons· 2 shared O. V. Vieira· 2 shared R. Matthiesen· 2 shared W. Vaz· 2 shared A. H. Futerman· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersPathology

C. Klose

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Author profile →

2 papers

Recent·Most cited

Cholesteryl hemiazelate Identified in Cardiovascular Disease Patients Causes in vitro and in vivo Inflammation

N. Domingues, J. Gaifem, R. Matthiesen, D. Saraiva, L. Bento, A. Marques, I. Soares, J. Sampaio, C. Klose, M. Surma, M. Almeida, G. Mendes, P. Goncalves, J. Ferreira, R. Gouveia e Melo, , O. V. Vieira

The paper identifies cholesteryl hemiazelate (ChA) as an oxidized lipid that induces inflammation in vitro and in vivo, contributing to atherosclerosis.

bioRxiv · Feb 9, 2023 · PreprintPathology

Cholesteryl Hemiazelate Induces Lysosome Dysfunction and Exocytosis in Macrophages

N. Domingues, R. D. A. Calado, P. Brito, R. Matthiesen, J. Ramalho, M. I. L. Soares, T. Pereira, L. Oliveira, J. Vicente, L. H. Wong, S. M. Cho, I. Simoes, J. Sampaio, C. Klose, M. A. Surma, , O. V. Vieira

This study identifies cholesteryl hemiazelate as a cause of lysosome dysfunction and exocytosis in macrophages, contributing to atherosclerosis.

bioRxiv · Jan 5, 2021 · PreprintCell Biology