M. A. Surma

Progranulin deficiency results in reduced bis(monoacylglycero)phosphate (BMP) levels and gangliosidosis

This study shows that progranulin deficiency reduces bis(monoacylglycero)phosphate levels, leading to gangliosidosis and neurodegeneration.

Flexibility of a mammalian lipidome - insights from mouse lipidomics

The paper investigates how diet, sex, and genotype affect the mouse lipidome across tissues, organs, and bodily fluids, providing baseline lipidomic data and insights into organ-specific flexibility.

Acyl chain shortening induced by inhibition of acetyl-CoA carboxylase renders phosphatidylcholine redundant

This study shows that acyl chain shortening via ACC1 inhibition allows yeast to grow without phosphatidylcholine by altering lipid biosynthesis pathways.

Cholesteryl Hemiazelate Induces Lysosome Dysfunction and Exocytosis in Macrophages

This study identifies cholesteryl hemiazelate as a cause of lysosome dysfunction and exocytosis in macrophages, contributing to atherosclerosis.

Environmentally induced lipidome adaptation in the bacterial model organism M. extorquens

The paper examines lipidome adaptation in M. extorquens under various environmental stresses and finds that few lipids drive most changes, with temperature having the greatest impact.

Comprehensive and quantitative analysis of white and brown adipose tissue by shotgun lipidomics

This paper presents a validated shotgun lipidomics method for adipose tissue, revealing diet-related lipidomic differences in brown, gonadal, and inguinal subcutaneous fat from lean and obese mice.