J. Ferreira

Cholesteryl hemiazelate Identified in Cardiovascular Disease Patients Causes in vitro and in vivo Inflammation

The paper identifies cholesteryl hemiazelate (ChA) as an oxidized lipid that induces inflammation in vitro and in vivo, contributing to atherosclerosis.

Soluble adenylyl cyclase inhibition prevents human sperm functions essential for fertilization

This study shows that inhibiting soluble adenylyl cyclase (sAC) in human sperm prevents key functions needed for fertilization, suggesting sAC inhibitors as potential non-hormonal contraceptives.

Mild impairment of mitochondrial function increases longevity and pathogen resistance through ATFS-1-driven activation of p38-regulated innate immunity

This paper shows that mild mitochondrial dysfunction in C. elegans extends lifespan and enhances pathogen resistance via ATFS-1-driven activation of p38-regulated innate immunity.

Adult zebrafish anaesthesia: a study of efficacy and behavioural recovery of different anaesthetics

This study evaluates the efficacy and behavioural recovery of different anaesthetics in adult zebrafish, finding that all protocols allowed full recovery within 1 hour, with etomidate showing minor long-term behavioural effects.

Cholesteryl Hemiazelate Induces Lysosome Dysfunction and Exocytosis in Macrophages

This study identifies cholesteryl hemiazelate as a cause of lysosome dysfunction and exocytosis in macrophages, contributing to atherosclerosis.

Trackosome: a computational toolbox to study the spatiotemporal dynamics of centrosomes, nuclear envelope and cellular membrane

Trackosome tracks centrosomes and reconstructs nuclear and cellular membranes from live-imaging data, revealing correlations between centrosome movements and nuclear envelope oscillations.

DNA damage independent inhibition of NF-κB transcription by anthracyclines

This study shows anthracyclines inhibit NF-κB transcription without DNA damage, affecting inflammation independently of their DNA-damaging effects.

PD-1 and PD-L1 are diagnostic biomarkers and PD-L1 a promising therapeutic target in HER2-positive and triple negative normal-like feline mammary carcinoma subtypes

The paper compares PD-1 and PD-L1 levels in feline mammary carcinoma subtypes to healthy controls and identifies their potential as diagnostic biomarkers and therapeutic targets.