Systematic enhancement of protein crystallization efficiency by bulk lysine-to-arginine (KR) substitution
N. E. Banayan, B. J. Loughlin, S. Singh, F. Forouhar, G. Lu, K.-H. Wong, M. Neky, H. S. Hunt, L. B. Bateman, A. Tamez, S. K. Handelman, W. N. Price, J. F. Hunt
This study shows that bulk lysine-to-arginine substitutions improve protein crystallization by enhancing hydrogen bonding at crystal interfaces.
bioRxiv · Jun 3, 2023Biophysics