Author

B. J. Loughlin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Assay:cryo-EM· 1 Research Focus:host-pathogen & immune response· 1 Assay:protein structure· 1

Frequent Co-Authors

J. F. Hunt· 2 shared K.-H. Wong· 2 shared S. Singh· 2 shared A. Mezzell· 1 shared A. Tamez· 1 shared C. G. Brouillette· 1 shared C. Wang· 1 shared D. R. Wetmore· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersBiophysics

J. F. Hunt

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2 papers

Recent·Most cited

Systematic enhancement of protein crystallization efficiency by bulk lysine-to-arginine (KR) substitution

N. E. Banayan, B. J. Loughlin, S. Singh, F. Forouhar, G. Lu, K.-H. Wong, M. Neky, H. S. Hunt, L. B. Bateman, A. Tamez, S. K. Handelman, W. N. Price, J. F. Hunt

This study shows that bulk lysine-to-arginine substitutions improve protein crystallization by enhancing hydrogen bonding at crystal interfaces.

bioRxiv · Jun 3, 2023Biophysics

Mechanism of dual pharmacological correction and potentiation of human CFTR

C. Wang, Z. Yang, B. J. Loughlin, H. Xu, G. Veit, S. Vorobiev, O. B. Clarke, F. Jiang, Y. Li, S. Singh, Z. Rich, E. R. Menten, R. A. Grassucci, W. Wang, A. Mezzell, , J. F. Hunt

This paper uses cryo-EM to reveal how VX445 corrects CFTR folding and gating defects by altering allosteric communication pathways.

bioRxiv · Oct 10, 2022 · PreprintBiophysics