Author

S. K. Handelman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 1 Biophysics· 1 Cancer Biology· 1 Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 4 Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:GWAS summary statistics· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

J. Z. Sexton· 2 shared S. M. McCarty· 2 shared A. Ade· 1 shared A. Allyn-Feurer· 1 shared A. Kuppa· 1 shared A. Pant· 1 shared A. T. Amin· 1 shared A. Tamez· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCell Biology

J. Z. Sexton

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Systematic enhancement of protein crystallization efficiency by bulk lysine-to-arginine (KR) substitution

N. E. Banayan, B. J. Loughlin, S. Singh, F. Forouhar, G. Lu, K.-H. Wong, M. Neky, H. S. Hunt, L. B. Bateman, A. Tamez, S. K. Handelman, W. N. Price, J. F. Hunt

This study shows that bulk lysine-to-arginine substitutions improve protein crystallization by enhancing hydrogen bonding at crystal interfaces.

bioRxiv · Jun 3, 2023Biophysics

Morphological Cell Profiling of SARS-CoV-2 Infection Identifies Drug Repurposing Candidates for COVID-19

C. Mirabelli, J. W. Wotring, C. J. Zhang, S. M. McCarty, R. Fursmidt, T. Frum, N. S. Kadambi, A. T. Amin, T. R. O'Meara, C. D. Pretto-Kernahan, J. R. Spence, J. Huang, K. D. Alysandratos, D. N. Kotton, S. K. Handelman, , J. Z. Sexton

This study identifies 17 FDA-approved compounds with antiviral efficacy against SARS-CoV-2 using high-throughput screening and finds lactoferrin as a promising drug candidate with multiple antiviral mechanisms.

Proceedings of the National Academy of Sciences · Aug 19, 2021Peer-reviewedCell Biology

Knockout of murine Lyplal1 confers sex-specific protection against diet-induced obesity

R. B. Vohnoutka, A. Kuppa, Y. Hegde, Y. Chen, A. Pant, E.-Y. K. Choi, S. M. McCarty, D. Bagchi, X. Du, Y. Chen, V. L. Chen, L. F. Bielak, L. H. Maguire, S. K. Handelman, J. Z. Sexton, , E. K. Speliotes

This study shows that knocking out Lyplal1 in mice leads to sex-specific protection against diet-induced obesity, mirroring human genetic findings.

bioRxiv · Aug 5, 2021Biochemistry

Ketamine's pharmacogenomic network in human brain contains sub-networks associated with glutamate neurotransmission and with neuroplasticity

G. A. Higgins, S. K. Handelman, A. Allyn-Feurer, A. Ade, J. S. Burns, G. S. Omenn, B. D. Athey

The paper identifies sub-networks within the ketamine pharmacogenomic network in the human brain associated with glutamate neurotransmission, neuroplasticity, and pharmacokinetics.

bioRxiv · Apr 28, 2020 · PreprintPharmacology & Toxicology

Mitigating Temozolomide Resistance in Glioblastoma via DNA Damage-Repair Inhibition

I. C. Sorribes, S. K. Handelman, H. V. Jain

This study develops a mechanistic model to identify optimal combination therapies for overcoming temozolomide resistance in glioblastoma by targeting DNA repair enzymes.

bioRxiv · Oct 5, 2019Cancer Biology