Author

K.-H. Wong

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:protein folding & dynamics· 3 Assay:cryo-EM· 2 Organism:E. coli· 2 Organism:human· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

J. F. Hunt· 4 shared S. Singh· 4 shared B. J. Loughlin· 2 shared C. Wang· 2 shared G. Boël· 2 shared J. Frank· 2 shared M. J. Neky· 2 shared N. A. Bailey· 2 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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4 shared papersBiophysics

J. F. Hunt

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Author profile →

4 papers

Recent·Most cited

Cryo-EM studies of the four E. coli paralogs establish ABCF proteins as master plumbers of the peptidyl-transferase center of the ribosome

S. Singh, R. C. Gentry, Z. Fu, N. A. Bailey, C. G. Altomare, K.-H. Wong, M. J. Neky, C. Wang, K. K. Ray, Y.-C. Chi, Z. Zhang, R. A. Grassucci, J. Frank, G. Boël, R. L. Gonzalez, J. F. Hunt

This study presents cryo-EM structures of four E. coli ABCF paralogs bound to the ribosome, revealing their role in modulating tRNA geometry and catalytic function at the peptidyl-transferase center.

bioRxiv · Jun 15, 2023 · PreprintBiophysics

Comparative genetic, biochemical, and biophysical analyses of the four E. coli ABCF paralogs support distinct functions related to mRNA translation

F. Ousalem, S. Singh, N. A. Bailey, K.-H. Wong, L. Zhu, M. J. Neky, C. Sibindi, J. Fei, R. L. Gonzalez, G. Boël, J. F. Hunt

The paper compares four E. coli ABCF paralogs to determine their distinct roles in mRNA translation using biochemical and biophysical assays.

bioRxiv · Jun 11, 2023 · PreprintBiochemistry

Systematic enhancement of protein crystallization efficiency by bulk lysine-to-arginine (KR) substitution

N. E. Banayan, B. J. Loughlin, S. Singh, F. Forouhar, G. Lu, K.-H. Wong, M. Neky, H. S. Hunt, L. B. Bateman, A. Tamez, S. K. Handelman, W. N. Price, J. F. Hunt

This study shows that bulk lysine-to-arginine substitutions improve protein crystallization by enhancing hydrogen bonding at crystal interfaces.

bioRxiv · Jun 3, 2023Biophysics

Mechanism of dual pharmacological correction and potentiation of human CFTR

C. Wang, Z. Yang, B. J. Loughlin, H. Xu, G. Veit, S. Vorobiev, O. B. Clarke, F. Jiang, Y. Li, S. Singh, Z. Rich, E. R. Menten, R. A. Grassucci, W. Wang, A. Mezzell, , J. F. Hunt

This paper uses cryo-EM to reveal how VX445 corrects CFTR folding and gating defects by altering allosteric communication pathways.

bioRxiv · Oct 10, 2022 · PreprintBiophysics