Author

F. Forouhar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Assay:protein structure· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1 Assay:metagenomics· 1

Frequent Co-Authors

A. A. Ferrando· 1 shared A. Chavez· 1 shared A. Mo· 1 shared A. Tamez· 1 shared A. Zask· 1 shared B. J. Loughlin· 1 shared B. R. Stockwell· 1 shared B.-y. Hong· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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1 shared paperCancer Biology

A. A. Ferrando

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Author profile →

4 papers

Recent·Most cited

Systematic enhancement of protein crystallization efficiency by bulk lysine-to-arginine (KR) substitution

N. E. Banayan, B. J. Loughlin, S. Singh, F. Forouhar, G. Lu, K.-H. Wong, M. Neky, H. S. Hunt, L. B. Bateman, A. Tamez, S. K. Handelman, W. N. Price, J. F. Hunt

This study shows that bulk lysine-to-arginine substitutions improve protein crystallization by enhancing hydrogen bonding at crystal interfaces.

bioRxiv · Jun 3, 2023Biophysics

Computational structure prediction methods enable the systematic identification of oncogenic mutations

X. Fu, C. Reglero, V. Swamy, J. W. Loh, H. Khiabanian, R. Albero, F. Forouhar, M. Al Quraishi, A. A. Ferrando, R. Rabadan

This paper introduces a computational method to identify oncogenic mutations by integrating evolutionary information and protein structure prediction, demonstrating its effectiveness in pediatric leukemias.

bioRxiv · Nov 18, 2022 · PreprintCancer Biology

Lead compounds for the development of SARS-CoV-2 3CL protease inhibitors

S. Iketani, F. Forouhar, H. Liu, S. J. Hong, F.-Y. Lin, M. S. Nair, A. Zask, Y. Huang, L. Xing, B. R. Stockwell, A. Chavez, D. D. Ho

The paper identifies three structurally diverse compounds as inhibitors of the SARS-CoV-2 3CL protease and provides structural insights for inhibitor design.

bioRxiv · Aug 3, 2020Microbiology

Characterization of Mucosal Dysbiosis of Early Colonic Neoplasia

B.-y. Hong, T. Ideta, Y. Igarashi, Y. Tan, M. DiSiena, A. Mo, J. W. Birk, F. Forouhar, T. J. Devers, G. M. Weinstock, D. W. Rosenberg

This study characterizes mucosal dysbiosis in early colonic neoplasia, finding associations between specific bacterial species and colorectal cancer mutations.

bioRxiv · Jun 6, 2019Microbiology