N. E. Harrington

How long does it take to cue a Pseudomonas aeruginosa chronic infection phenotype in the lab? Insights from transcriptome analysis in a cystic fibrosis lung model.

This study investigates how quickly Pseudomonas aeruginosa develops chronic infection traits in a CF lung model over 7 days, showing increased antibiotic tolerance and biofilm formation.

Transcriptome analysis of Pseudomonas aeruginosa biofilm infection in an ex vivo pig model of the cystic fibrosis lung

The paper compares Pseudomonas aeruginosa transcriptomes in an ex vivo pig lung model and synthetic cystic fibrosis sputum medium to show the EVPL model better replicates in vivo biofilm infection characteristics and antimicrobial resistance.

Predicting antibiotic-associated virulence of Pseudomonas aeruginosa using an ex-vivo lung biofilm model

This study uses an ex-vivo lung biofilm model to assess antibiotic tolerance and virulence of Pseudomonas aeruginosa, showing minimal bacterial load reduction and increased virulence factors with certain antibiotics.

Building a better biofilm - formation of in vivo-like biofilm structures by Pseudomonas aeruginosa in a porcine model of cystic fibrosis lung infection

This study optimizes an ex vivo pig lung model to mimic in vivo Pseudomonas aeruginosa biofilm structure in CF lung infections, identifying key metabolic and genetic factors essential for biofilm formation.

An ex vivo cystic fibrosis model recapitulates key clinical aspects of chronic Staphylococcus aureus infection

This study develops an ex vivo pig lung model of cystic fibrosis to study Staphylococcus aureus infection, showing clinically relevant features like small colony variants and antibiotic tolerance.