E. Sweeney

Effect of host-mimicking medium and biofilm growth on the ability of colistin to kill Pseudomonas aeruginosa.

This study shows that Pseudomonas aeruginosa in CF-mimicking media and ex vivo models exhibits higher colistin tolerance due to poor antibiotic penetration, highlighting the need for better biofilm penetration assays.

Predicting antibiotic-associated virulence of Pseudomonas aeruginosa using an ex-vivo lung biofilm model

This study uses an ex-vivo lung biofilm model to assess antibiotic tolerance and virulence of Pseudomonas aeruginosa, showing minimal bacterial load reduction and increased virulence factors with certain antibiotics.

Building a better biofilm - formation of in vivo-like biofilm structures by Pseudomonas aeruginosa in a porcine model of cystic fibrosis lung infection

This study optimizes an ex vivo pig lung model to mimic in vivo Pseudomonas aeruginosa biofilm structure in CF lung infections, identifying key metabolic and genetic factors essential for biofilm formation.

An ex vivo cystic fibrosis model recapitulates key clinical aspects of chronic Staphylococcus aureus infection

This study develops an ex vivo pig lung model of cystic fibrosis to study Staphylococcus aureus infection, showing clinically relevant features like small colony variants and antibiotic tolerance.