M. M. Hassan

Designing Bt constructs for Brassicas, with minimal IP issues: A case study

The paper designs modified Bt Cry1BM and Cry1CM genes for Brassicas to reduce licensing costs and IP issues, showing high insecticidal efficacy in transgenic Arabidopsis.

High-resolution comparative atomic structures of two Giardiavirus prototypes infecting G.duodenalis parasite

This study presents high-resolution atomic structures of two Giardiavirus strains, revealing structural features associated with extracellular transmission and virulence in Giardia duodenalis.

Exploration of the Tunability of BRD4 Degradation by DCAF16 Trans-labelling Covalent Glues

This study evaluates how electrophilic modifications to JQ1 affect DCAF16 trans-labeling and BRD4 degradation, showing a correlation between warhead exposure and degradation efficiency.

Discovery of specific activity of 2-HPA acting on the membrane progestin receptor α (paqr7) by purification of natural products from the marine algae Padina

This study identifies 2-HPA as a novel mPR antagonist from marine algae Padina arborescens, showing specific inhibitory activity in vitro and in vivo.

The Plasminogen-Apple-Nematode (PAN) domain suppresses JA/ET defense pathways in plants

The study shows the PAN domain in G-type lectin receptor-like kinases suppresses JA/ET defense pathways in plants by promoting receptor degradation.

Template-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders

This paper describes a new mechanism for molecular glue degraders called template-assisted covalent modification, showing how BRD4 degraders recruit CUL4DCAF16 to degrade BRD4.

Split selectable marker mediated gene stacking in plants

This paper introduces a split selectable marker system using inteins for Agrobacterium-mediated co-transformation in plants, enabling the simultaneous insertion of multiple genes into Arabidopsis and poplar.

Phytochemical and antibacterial analyses of Onychium japonicum (Thunb.) Kunze.

This study investigates the phytochemical composition and antibacterial potential of Onychium japonicum, finding it rich in bioactive compounds and active against multidrug-resistant bacteria.

An intein-mediated split-nCas9 system for base editing in plants

This paper develops a split-nCas9 system using intein-mediated reassembly for efficient base editing in plants.

Plant-based biosensors for detecting CRISPR-mediated genome engineering

This study develops plant-based biosensors to detect CRISPR/Cas tools in real-time, demonstrating their effectiveness in detecting various CRISPR functions in multiple plant species.

Phodopus roborovskii SH101 as a systemic infection model of SARS-CoV-2

This paper identifies a hamster model, Phodopus roborovskii SH101, that exhibits systemic SARS-CoV-2 infection with clinical symptoms similar to human COVID-19.

Predicting antibiotic-associated virulence of Pseudomonas aeruginosa using an ex-vivo lung biofilm model

This study uses an ex-vivo lung biofilm model to assess antibiotic tolerance and virulence of Pseudomonas aeruginosa, showing minimal bacterial load reduction and increased virulence factors with certain antibiotics.

An ex vivo cystic fibrosis model recapitulates key clinical aspects of chronic Staphylococcus aureus infection

This study develops an ex vivo pig lung model of cystic fibrosis to study Staphylococcus aureus infection, showing clinically relevant features like small colony variants and antibiotic tolerance.