Author

N. G. Fox

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:biophysical modeling· 1 Assay:cryo-EM· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

A. Martelli· 2 shared C. Bulawa· 2 shared J. F. Nabhan· 2 shared C. Strain-Damerell· 1 shared H. J. Bailey· 1 shared J. Janz· 1 shared O. Borkowska· 1 shared S. Han· 1 shared

Activity by Year

2018-2019 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

A. Martelli

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2 papers

Recent·Most cited

Structure of the human frataxin-bound iron-sulfur cluster assembly complex provides insight into its activation mechanism

N. G. Fox, X. Yu, X. Feng, H. J. Bailey, A. Martelli, J. F. Nabhan, C. Strain-Damerell, C. Bulawa, W. W. Yue, S. Han

The paper determines the cryo-EM structure of the FXN-bound active human ISC biosynthesis complex, revealing how FXN activates NFS1 by removing zinc inhibition and stabilizing protein interfaces.

bioRxiv · Feb 28, 2019Biochemistry

Zinc(II) binding on human wild-type ISCU and Met140 variants modulates Fe-S complex activity

N. G. Fox, A. Martelli, J. F. Nabhan, J. Janz, O. Borkowska, C. Bulawa, W. Yue

This study investigates how zinc(II) binding to ISCU affects Fe-S cluster biosynthesis and shows that Met140 variants of ISCU do not bypass FXN's role in the absence of FXN.

bioRxiv · Feb 10, 2018Biochemistry