W. W. Yue

The paper determines cryo-EM structures of human MTHFR bound to SAM and SAH, revealing how inter-domain transformations mediate allosteric regulation by altering active site accessibility.

This study uses cryo-electron microscopy to reveal how human CBS regulates activity through conformational changes in its regulatory domain.

This study presents cryo-EM structures of phosphorylated human GYS1 complexed with GYG1, revealing how phosphorylation and glucose-6-phosphate regulate glycogen synthase activity.

The paper investigates how different cobamides affect the function of methylmalonyl-CoA mutase and shows that non-cobalamin cobamides can also support its activity.

This study presents the crystal structure of human DHTKD1 and a 3D reconstruction of the DLST inner core, revealing structural insights into lysine catabolism and potential drug targets.

The paper determines the cryo-EM structure of the FXN-bound active human ISC biosynthesis complex, revealing how FXN activates NFS1 by removing zinc inhibition and stabilizing protein interfaces.

The paper identifies ten new patients with MCEE deficiency, analyzes mutations in the MCEE gene, and reveals structural and functional defects in the enzyme caused by these mutations.