Author

W. Yue

Genome Institute of Singapore

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 4 Cell Biology· 4 Cancer Biology· 1 Genomics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 9 Organism:human· 8 Research Focus:cell type annotation· 3 Research Focus:chromatin & epigenetic regulation· 3 Approach:statistical model· 3 Assay:ChIP-seq· 2 Organism:mouse· 2 Research Focus:protein folding & dynamics· 2

Frequent Co-Authors

X. Wu· 3 shared A. Lei· 2 shared C. Bulawa· 2 shared H. Wang· 2 shared J. Hua· 2 shared J. Janz· 2 shared J. Zhang· 2 shared M. Liao· 2 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCell Biology

X. Wu

Mutual co-authors in cluster

Author profile →

11 papers

Recent·Most cited

Structural basis for human mitochondrial tRNA maturation

V. Meynier, S. W. Hardwick, M. Catala, J. Roske, S. Oerum, D. Y. Chirgadze, P. Barraud, W. Yue, B. Luisi, C. Tisne

This study reports cryo-EM structures of human mitochondrial tRNA maturation complexes, revealing the molecular mechanisms of tRNA processing steps and their sequential order.

Nature Communications · Jun 1, 2024Peer-reviewedBiochemistry

Jianpi Jiedu Recipe inhibits proliferation through reactive oxygen species-induced incomplete autophagy and reduces PD-L1 expression in colon cancer

L. Cheng, L. Xu, H. Yuan, Q. Zhao, W. Yue, S. Ma, X. Wu, D. Gu, Y. Sun, H. Shi, J. Xu

bioRxiv · Feb 15, 2024Pharmacology & Toxicology

CDC5L surveils cellular stress responses and stress granule formation through transcriptional repression

B. Qian, S. Li, Y. Duan, F. Qiu, R. Hu, W. Yue, J. Cui, Q. Wang, W. Li, Y. Fang

This study identifies CDC5L as a transcriptional repressor that prevents spontaneous stress granule formation by suppressing PERK-eIF2 signaling.

bioRxiv · Jan 4, 2024 · PreprintCell Biology

Decoding human in vitro terminal erythropoiesis originating from umbilical cord blood mononuclear cells and pluripotent stem cells

X. Wang, W. Zhang, S. Zhao, H. Yan, Z. Xin, T. Cui, R. Zang, L. Zhao, H. Wang, J. Zhou, X. Li, W. Yue, J. Xi, Z. Zhang, X. Fang, X. Pei

This study maps ex vivo terminal erythropoiesis from umbilical cord blood mononuclear cells and pluripotent stem cells, identifying differences in regulatory dynamics and CD99 expression affecting erythroid expansion and maturation.

bioRxiv · Apr 20, 2023 · PreprintCell Biology

Engineering GliaTrap: a biodegradable non-swelling hydrogel with tuned release of CXCL12 to attract migrating glioblastoma cells

Y. Suita, S. Miriyala, D. Merih-Toruner, W. Yue, L. Xie, B. Akobundu, N. Perch, A. Fiser, E. Fajardo, J. Shen, N. Tapinos

GliaTrap is a biodegradable non-swelling hydrogel with tuned release of a chemoattractant to attract invading glioma cells and serve as delivery platform for local therapeutics.

bioRxiv · Apr 12, 2023 · PreprintCancer Biology

Deeply conserved super-enhancers maintain stem cell pluripotency in placental mammals

J. Zhang, J. Hua, W. Wang, M. Liao, N. Li, Y. Zhou, W. Yue, Z. Zhu, Q. Shen, S. Yu, X. Wu, Q. Pan, W. Xu, R. Zhang, X. Wu, , Y. Li

The paper identifies three deeply conserved super-enhancers in placental mammals that are essential for maintaining stem cell pluripotency.

bioRxiv · May 3, 2022 · PreprintCell Biology

Snapshots of actin and tubulin folding inside the TRiC chaperonin

J. J. Kelly, D. Tranter, E. Pardon, G. Chi, H. Kramer, K. Knee, J. Janz, J. Steyaert, C. Bulawa, V. Paavilainen, J. Huiskonen, W. Yue

The paper captures structural snapshots of actin and tubulin folding within the TRiC chaperonin using cryo-EM, revealing how substrates interact with the chamber during folding.

bioRxiv · Mar 26, 2021Biochemistry

Histone demethylase complexes KDM3A and KDM3B cooperate with OCT4/SOX2 to construct pluripotency gene regulatory network

Z. Zhu, X. Wu, Q. Li, J. Zhang, S. Yu, Q. Shen, Z. Zhou, Q. Pan, W. Yue, D. Qin, Y. Zhang, W. Zhao, R. Zhang, S. Peng, N. Li, , x. chen

The paper shows that KDM3A and KDM3B, along with OCT4/SOX2, regulate H3K9 methylation to maintain pluripotency in porcine-induced pluripotent stem cells.

bioRxiv · Aug 16, 2020Cell Biology

Genome-wide Associations of Flavivirus Capsid Proteins

Priscilla Li Shan Boon, Ana Sofia Dias Martins, Francisco J. Enguita, Xin-Ni Lim, Nuno C. Santos, Paul Thomas Matsudaira, Ivo Cristiano Martins, W. Yue, Peter John Bond, Roland G. Huber

The paper maps the genome-wide association of capsid proteins with viral RNA in Dengue and Zika viruses, showing non-uniform binding patterns and sequence preferences.

bioRxiv · Apr 11, 2019 · PreprintGenomics

Structural basis of human 5,10-methylenetetrahydrofolate reductase (MTHFR) regulation by phosphorylation and S-adenosylmethionine inhibition

D. S. Froese, J. Kopec, E. Rembeza, G. A. Bezerra, A. Oberholzer, T. Suormala, S. Lutz, R. Chalk, O. Borkowska, M. Baumgartner, W. Yue

This study presents the 2.5 Å resolution crystal structure of human MTHFR, revealing its architecture and how phosphorylation and SAM binding regulate its activity.

bioRxiv · Feb 26, 2018Biochemistry

Zinc(II) binding on human wild-type ISCU and Met140 variants modulates Fe-S complex activity

N. G. Fox, A. Martelli, J. F. Nabhan, J. Janz, O. Borkowska, C. Bulawa, W. Yue

This study investigates how zinc(II) binding to ISCU affects Fe-S cluster biosynthesis and shows that Met140 variants of ISCU do not bypass FXN's role in the absence of FXN.

bioRxiv · Feb 10, 2018Biochemistry