N. G. Karlsson

This study identifies sialidases and fucosidases in Akkermansia muciniphila that degrade mucin glycans and enable nutrient sharing with gut bacteria.

This paper develops an ovine model of NSTEMI and identifies ECM and glycan alterations in post-ischaemic tissue.

This study finds that synovial levels of IL-8, MIP-1α, and VEGFA correlate with lubricin glycan truncation in OA, suggesting a link between glycan changes and local inflammation.

This study identifies a single sulfatase essential for colonic mucin O-glycan metabolism and intestinal colonization by Bacteroides thetaiotaomicron.

The paper identifies HMO utilization pathways in Roseburia and Eubacterium that enable co-growth with Akkermansia muciniphilia and highlight distinct HMO utilization phylotypes in the early gut microbiota.

The paper analyzes glycan composition in human neutrophil granules to show maturation-dependent glycosylation changes during granulopoiesis.

The paper shows that core-2 O-glycans are necessary for galectin-3 to bind lubricin, and this interaction is reduced in late-stage osteoarthritis.

This study shows that cathepsin G degrades lubricin in synovial fluid, contributing to osteoarthritis pathogenesis by reducing joint lubrication.