Inhibitor of apoptosis, IAP, genes play a critical role in the survival of HIV-infected macrophages
A. Kumar, R. E. H. Caballero, S. X. M. Dong, N. Gajanayaka, H. Ali, E. Cassol, W. Cameron, R. Korneluk, M. Tremblay, J. Angel
This study shows that SMAC-mimetics induce apoptosis in HIV-infected macrophages by targeting IAPs, suggesting IAP modulation as a strategy for eliminating viral reservoirs.
bioRxiv · Feb 6, 2019 · PreprintImmunology