Protein Tyrosine Phosphatase 1B Regulates MicroRNA-208b-Argonaute 2 Association and Thyroid Hormone Responsiveness in Cardiac Hypertrophy
G. Coulis, Y. Shi, D. P. Labbe, A. Bergeron, F. Sahmi, V. Vinette, G. Karsenty, B. G. Allen, M. Tremblay, J.-C. Tardif, B. Boivin
This study shows that PTP1B inactivation disrupts miR-208b-Argonaute 2 interaction, leading to increased THRAP1 expression and thyroid hormone-induced cardiac hypertrophy.
bioRxiv · Sep 10, 2019 · PreprintCell Biology