Acquired Cross-resistance in Small Cell Lung Cancer due to Extrachromosomal DNA Amplification of MYC paralogs
S. Pal Choudhuri, L. Girard, J. Y. S. Lim, J. F. Wise, B. Freitas, D. Yang, E. Wong, S. Hamilton, V. Chien, S. Phat, C. Gilbreath, J. Zhong, D. T. Myers, C. L. Christensen, M. Stanzione, , B. J. Drapkin
This paper identifies extrachromosomal DNA amplification of MYC paralogs as a recurrent driver of acquired cross-resistance in small cell lung cancer using patient-derived xenograft models.
bioRxiv · Jun 23, 2023 · PreprintCancer Biology