Author

M. S. Lawrence

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Assay:DNA methylation· 2

Frequent Co-Authors

G. Getz· 2 shared L. V. Sequist· 2 shared M. Stanzione· 2 shared N. J. Dyson· 2 shared A. Abbasi· 1 shared A. Bardia· 1 shared A. Deshpande· 1 shared A. F. Farago· 1 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersCancer Biology

G. Getz

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Tumor cell-based liquid biopsy using high-throughput microfluidic enrichment of entire leukapheresis product

A. Mishra, S.-B. Huang, T. Dubash, R. Burr, B. S. Wittner, Q. E. Cunneely, V. R. Putaturo, A. Deshpande, E. Antmen, K. A. Gopinathan, K. Otani, Y. Miyazawa, J. E. Kwak, S. Y. Guay, J. Kelly, , M. Toner

This study uses high-throughput microfluidic technology to enrich CTCs from large blood volumes, enabling detailed molecular and morphological analysis of tumor cells in metastatic cancer patients.

bioRxiv · Mar 13, 2024 · PreprintBioengineering

Distinguishing preferences of human APOBEC3A and APOBEC3B for cytosines in hairpin loops, and reflection of these preferences in APOBEC-signature cancer genome mutations

A. S. Bhagwat, Y. Butt, R. Sakhtemani, R. Mohamad-Ramshan, M. S. Lawrence

This study identifies distinct preferences of APOBEC3A and APOBEC3B for cytosines in hairpin loops and shows these preferences reflect in cancer genome mutations.

bioRxiv · Aug 1, 2023Cancer Biology

Acquired Cross-resistance in Small Cell Lung Cancer due to Extrachromosomal DNA Amplification of MYC paralogs

S. Pal Choudhuri, L. Girard, J. Y. S. Lim, J. F. Wise, B. Freitas, D. Yang, E. Wong, S. Hamilton, V. Chien, S. Phat, C. Gilbreath, J. Zhong, D. T. Myers, C. L. Christensen, M. Stanzione, , B. J. Drapkin

This paper identifies extrachromosomal DNA amplification of MYC paralogs as a recurrent driver of acquired cross-resistance in small cell lung cancer using patient-derived xenograft models.

bioRxiv · Jun 23, 2023 · PreprintCancer Biology

APOBEC3A drives acquired resistance to targeted therapies in non-small cell lung cancer

H. Isozaki, A. Abbasi, N. Nikpour, A. Langenbucher, W. Su, M. Stanzione, H. Frisco-Cabanos, F. M. Siddiqui, N. Phan, P. Jalili, S. Oh, D. Timonina, S. Bilton, M. Gomez-Caraballo, H. L. Archibald, , A. N. Hata

This study shows that APOBEC3A mutagenesis driven by targeted therapies promotes drug resistance in non-small cell lung cancer.

bioRxiv · Jan 20, 2021Cancer Biology

Expanding discovery from cancer genomes by integrating protein network analyses with in vivo tumorigenesis assays

H. Horn, M. S. Lawrence, C. R. Chouinard, Y. Shrestha, J. Xin Hu, E. Worstell, E. Shea, N. Ilic, E. Kim, A. Kamburov, A. Kashani, J. D. Campbell, W. C. Hahn, J. S. Boehm, G. Getz, K. Lage

The paper develops a method to identify new cancer genes by integrating protein network analysis with in vivo tumorigenesis assays, finding 62 new candidates and validating two in patient data.

bioRxiv · Oct 30, 2017Cancer Biology