L. Girard

Acquired Cross-resistance in Small Cell Lung Cancer due to Extrachromosomal DNA Amplification of MYC paralogs

This paper identifies extrachromosomal DNA amplification of MYC paralogs as a recurrent driver of acquired cross-resistance in small cell lung cancer using patient-derived xenograft models.

ASCL1-ERK1/2 Axis: ASCL1 restrains ERK1/2 via the dual specificity phosphatase DUSP6 to promote survival of a subset of neuroendocrine lung cancers

This study identifies the ASCL1-DUSP6-ERK1/2 axis as a mechanism promoting survival in neuroendocrine lung cancers, suggesting DUSP6 as a potential therapeutic target.

Brief report: Reclassifying SCLC-Y as SMARCA4 deficient malignancies - resolving the controversy

The paper reclassifies YAP1-expressing SCLC-Y as SMARCA4-deficient malignancies, showing they lack SCLC features and instead resemble SMARCA4-deficient tumors.

KSR2 promotes self-renewal and clonogenicity of small-cell lung carcinoma

This study shows KSR2 promotes self-renewal and clonogenicity in ASCL1-subtype SCLC by enhancing ERK signaling and tumor initiating capacity.

An NMR fingerprint matching approach for the identification and structural re-evaluation of Pseudomonas lipopeptides.

The paper introduces an NMR fingerprinting method to identify and re-evaluate the structure of Pseudomonas lipopeptides, enabling rapid differentiation between diastereomers and aiding dereplication.

Relationship Between Neuroendocrine and Immune Gene Expression in Small Cell Lung Cancer

This study examines the relationship between neuroendocrine and immune gene expression in SCLC, finding that variant SCLC tumors regain immune gene expression and exhibit higher tumor-immune interactions.

The hexosamine biosynthesis pathway is a targetable liability in lung cancers with concurrent KRAS and LKB1 mutations.

The paper identifies the hexosamine biosynthesis pathway as a metabolic vulnerability in KRAS/LKB1 mutant lung cancers and shows GFPT2 inhibition reduces tumor growth.

SCLC_CellMiner: Integrated Genomics and Therapeutics Predictors of Small Cell Lung Cancer Cell Lines based on their genomic signatures

SCLC_CellMiner provides an integrated resource of 118 SCLC cell lines with omics data and drug sensitivity, identifying molecular subtypes and therapeutic targets.

Stromal Hedgehog pathway activation by IHH suppresses lung adenocarcinoma growth and metastasis by limiting reactive oxygen species

This study shows that IHH activates the stromal Hedgehog pathway to suppress lung adenocarcinoma growth and metastasis by reducing reactive oxygen species.

METABOLIC DIVERSITY IN HUMAN NON-SMALL CELL LUNG CANCER CELLS

The paper quantifies metabolic features in NSCLC cell lines to explore associations between metabolism and other cell-autonomous processes.