An anti-steatosis response regulated by oleic acid through lipid droplet-mediated ERAD enhancement
J. I. Castillo-Quan, M. J. Steinbaugh, L. P. Fernandez-Cardenas, N. K. Pohl, Z. Wu, F. Zhu, N. Moroz, V. Teixeira, M. S. Bland, N. J. Lehrbach, L. E. M. Mazzeo, M. Teufl, T. K. Blackwell
This study shows oleic acid enhances ERAD via lipid droplets to increase SKN-1A levels, reducing steatosis and promoting longevity in C. elegans.
bioRxiv · Jun 15, 2022 · PreprintCell Biology