Molecular interactions underlying the phase separation of HP1: Role of phosphorylation, ligand and nucleic acid binding
C. Her, T. M. Phan, N. Jovic, U. Kapoor, B. E. Ackermann, A. Rizuan, Y. Kim, J. Mittal, G. T. Debelouchina
This study investigates how phosphorylation, ligand, and nucleic acid binding influence HP1's phase separation, revealing electrostatic interactions and conformational changes in its LLPS behavior.
bioRxiv · Jun 20, 2022Biophysics