Author

T. M. Phan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 5 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 3 Assay:protein structure· 3 Approach:statistical model· 3 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Organism:Drosophila· 1

Frequent Co-Authors

J. Mittal· 4 shared J. D. Schmit· 2 shared U. Kapoor· 2 shared Y. C. Kim· 2 shared A. Bihani· 1 shared A. Henrickson· 1 shared A. J. Mendiola· 1 shared A. Rizuan· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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4 shared papersBiophysics

J. Mittal

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Author profile →

6 papers

Recent·Most cited

Transient interdomain interactions modulate the monomeric structural ensemble and self-assembly of Huntingtin Exon 1

P. Mohanty, T. M. Phan, J. Mittal

This study uses molecular dynamics simulations to show that transient interdomain interactions in Httex1 modulate its structural ensemble and self-assembly, contributing to aggregation in Huntington's disease.

bioRxiv · May 3, 2024Biophysics

How a disordered linker in the Polycomb protein Polyhomeotic tunes phase separation and oligomerization

T. M. Gemeinhardt, R. M. Regy, T. M. Phan, N. Pal, J. Sharma, O. Senkovich, A. J. Mendiola, H. J. Ledterman, A. Henrickson, D. Lopes, U. Kapoor, A. Bihani, D. Sihou, Y. C. Kim, D. Jeruzalmi, , N. J. Francis

The paper investigates how a disordered linker in the Polyhomeotic protein influences phase separation and oligomerization in Drosophila and human cells through in vitro reconstitution and molecular dynamics simulations.

bioRxiv · Oct 26, 2023Biochemistry

Interplay between charge distribution and DNA in shaping HP1 paralog phase separation and localization

T. M. Phan, Y. C. Kim, G. Debelouchina, J. Mittal

This study investigates how charge distribution and DNA influence the phase separation and localization of HP1 paralogs using simulations.

bioRxiv · May 28, 2023Biophysics

Molecular interactions underlying the phase separation of HP1: Role of phosphorylation, ligand and nucleic acid binding

C. Her, T. M. Phan, N. Jovic, U. Kapoor, B. E. Ackermann, A. Rizuan, Y. Kim, J. Mittal, G. T. Debelouchina

This study investigates how phosphorylation, ligand, and nucleic acid binding influence HP1's phase separation, revealing electrostatic interactions and conformational changes in its LLPS behavior.

bioRxiv · Jun 20, 2022Biophysics

Beneficial and Detrimental Effects of Nonspecific Binding During DNA Hybridization

T. T. M. Phan, T. M. Phan, J. D. Schmit

This paper investigates how nonspecific binding during DNA hybridization impacts hybridization rates and native structure stability through three stages: diffusion, registry search, and zipping.

bioRxiv · Mar 31, 2022Biophysics

Conformational entropy limits the transition from nucleation to elongation in amyloid aggregation

T. M. Phan, J. D. Schmit

This paper uses simulations to model amyloid fibril formation, showing that conformational entropy limits the transition from nucleation to elongation in amyloid aggregation.

bioRxiv · Jun 22, 2020Biophysics