T. M. Perdikari

Molecular insights into the effect of hexanediol on FUS phase separation

This study investigates how alkanediols, particularly 1,6-hexanediol, disrupt FUS phase separation using multiple techniques and identifies factors like geometry and hydrophobicity that influence their effectiveness.

A predictive coarse-grained model for position-specific effects of post-translational modifications on disordered protein phase separation

This paper develops a coarse-grained model to predict how position-specific post-translational modifications affect disordered protein phase separation.

The oncogenic transcription factor FUS-CHOP can undergo nuclear liquid-liquid phase separation

This study shows the FUS-CHOP fusion protein undergoes nuclear liquid-liquid phase separation, forming condensates at super enhancer sites, suggesting a novel oncogenic mechanism in myxoid liposarcoma.

An enhancer sequence in the intrinsically disordered region of the essential cell division protein FtsZ promotes conformation-guided substrate processing by ClpXP in Escherichia coli

The paper shows that an intrinsically disordered region of FtsZ enhances ClpXP-mediated degradation through conformational interactions.

SARS-CoV-2 nucleocapsid protein undergoes liquid-liquid phase separation stimulated by RNA and partitions into phases of human ribonucleoproteins

This study shows SARS-CoV-2 nucleocapsid protein undergoes RNA-stimulated liquid-liquid phase separation, forming condensates with host RNA-binding proteins, which may aid viral genome packaging and host protein co-option.

Tyrosine phosphorylation regulates hnRNPA2 granule protein partitioning & reduces neurodegeneration

The paper shows tyrosine phosphorylation of hnRNPA2 reduces granule component partitioning and neurodegeneration in a C. elegans model.