Author

N. K. Goto

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 3 Assay:protein structure· 3 Approach:deep learning· 2 Approach:experimental assay· 1 Research Focus:protein design· 1 Assay:protein sequence· 1 Approach:statistical model· 1

Frequent Co-Authors

A. M. Damry· 3 shared R. A. Chica· 3 shared A. Broom· 1 shared A. D. St-Jacques· 1 shared J. A. Davey· 1 shared J. M. Rodriguez· 1 shared M. C. Thompson· 1 shared M. G. Eason· 1 shared

Activity by Year

2017-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersBiophysics

A. M. Damry

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3 papers

Recent·Most cited

Computational remodeling of an enzyme conformational landscape for altered substrate selectivity

A. D. St-Jacques, J. M. Rodriguez, M. G. Eason, S. M. Foster, S. T. Khan, A. M. Damry, N. K. Goto, M. C. Thompson, R. A. Chica

This study computationally redesigns an enzyme's conformational landscape to enhance catalytic efficiency with a non-native substrate, achieving up to 1900-fold selectivity switch.

bioRxiv · Sep 16, 2022Biophysics

Origin of Conformational Dynamics in a Globular Protein

A. M. Damry, M. M. Mayer, A. Broom, N. K. Goto, R. A. Chica

This study shows how two mutations can create conformational dynamics in a globular protein through synergistic effects on its energy landscape.

bioRxiv · Aug 4, 2019Biophysics

Rational design of proteins that exchange on functional timescales

J. A. Davey, A. M. Damry, N. K. Goto, R. A. Chica

This paper designs proteins that exchange between defined conformational states on functional timescales using a new computational method called meta-multistate design.

bioRxiv · Mar 3, 2017Biophysics