Author

R. A. Chica

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Assay:protein structure· 5 Research Focus:protein folding & dynamics· 4 Approach:deep learning· 3 Research Focus:protein design· 3 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:drug response / drug discovery· 1 Assay:protein sequence· 1

Frequent Co-Authors

A. M. Damry· 3 shared M. C. Thompson· 3 shared N. K. Goto· 3 shared A. Broom· 2 shared J. M. Rodriguez· 2 shared N. Zarifi· 2 shared R. V. Rakotoharisoa· 2 shared A. D. St-Jacques· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersBiophysics

A. M. Damry

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Author profile →

5 papers

Recent·Most cited

Design of efficient artificial enzymes using crystallographically-enhanced conformational sampling

R. V. Rakotoharisoa, B. Seifinoferest, N. Zarifi, J. D. M. Miller, J. M. Rodriguez, M. C. Thompson, R. A. Chica

This paper designs artificial enzymes with high catalytic efficiency using crystallography-enhanced computational methods, achieving improvements comparable to directed evolution.

bioRxiv · Nov 1, 2023Biochemistry

Computational remodeling of an enzyme conformational landscape for altered substrate selectivity

A. D. St-Jacques, J. M. Rodriguez, M. G. Eason, S. M. Foster, S. T. Khan, A. M. Damry, N. K. Goto, M. C. Thompson, R. A. Chica

This study computationally redesigns an enzyme's conformational landscape to enhance catalytic efficiency with a non-native substrate, achieving up to 1900-fold selectivity switch.

bioRxiv · Sep 16, 2022Biophysics

Evolution of an enzyme conformational ensemble guides design of an efficient biocatalyst

A. Broom, R. V. Rakotoharisoa, M. C. Thompson, N. Zarifi, E. Nguyen, N. Mukhametzhanov, L. Liu, J. S. Fraser, R. A. Chica

The paper uses X-ray crystallography to study conformational changes in an evolved enzyme, leading to the design of a more efficient biocatalyst by focusing on active-site mutations.

bioRxiv · Mar 19, 2020Biophysics

Origin of Conformational Dynamics in a Globular Protein

A. M. Damry, M. M. Mayer, A. Broom, N. K. Goto, R. A. Chica

This study shows how two mutations can create conformational dynamics in a globular protein through synergistic effects on its energy landscape.

bioRxiv · Aug 4, 2019Biophysics

Rational design of proteins that exchange on functional timescales

J. A. Davey, A. M. Damry, N. K. Goto, R. A. Chica

This paper designs proteins that exchange between defined conformational states on functional timescales using a new computational method called meta-multistate design.

bioRxiv · Mar 3, 2017Biophysics