Author

N. K. Khandelwal

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 4 Approach:experimental assay· 4 Organism:yeast· 4 Research Focus:protein structure prediction· 3 Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

T. M. Tomasiak· 4 shared C. F. Hotze· 1 shared C. R. Millan· 1 shared D. Williams· 1 shared M. S. I. Rasel· 1 shared R. S. A. de Carvalho· 1 shared S. Avila· 1 shared S. I. Zangari· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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4 shared papersBiochemistry

T. M. Tomasiak

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4 papers

Recent·Most cited

Cryo-EM structure of the tetra-phosphorylated R-domain in Ycf1 reveals key interactions for transport regulation

R. S. A. de Carvalho, M. S. I. Rasel, N. K. Khandelwal, T. M. Tomasiak

The paper determines the cryo-EM structure of the tetra-phosphorylated R-domain in Ycf1, revealing key interactions that regulate transport.

bioRxiv · Mar 6, 2024Biochemistry

Structural Basis for Oxidized Glutathione Recognition by the Yeast Cadmium Factor 1

T. H. Soong, C. F. Hotze, N. K. Khandelwal, T. M. Tomasiak

The paper determines the cryo-EM structure of Ycf1 bound to oxidized glutathione and identifies a 'flex-pocket' mechanism for substrate binding and specificity.

bioRxiv · Jan 31, 2024Biochemistry

Structural Basis for Autoinhibition by the Dephosphorylated Regulatory Domain of Ycf1

N. K. Khandelwal, T. M. Tomasiak

This study determines the structure of dephosphorylated Ycf1 using cryo-EM, revealing an ordered R-domain topology that mediates autoinhibition and provides insights into its phosphorylation-dependent activation mechanism.

bioRxiv · Jun 22, 2023Biochemistry

The structural basis for regulation of the glutathione transporter Ycf1 by regulatory domain phosphorylation

N. K. Khandelwal, C. R. Millan, S. I. Zangari, S. Avila, D. Williams, T. M. Thaker, T. M. Tomasiak

This study presents cryo-EM structures of Ycf1 showing how phosphorylation of the regulatory domain modulates its interaction with NBD1 and affects ATPase activity.

bioRxiv · Jun 18, 2021Biochemistry