Author

T. M. Thaker

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 2 Biophysics· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Assay:cryo-EM· 3 Organism:bacteria (other)· 2 Research Focus:protein folding & dynamics· 2 Research Focus:protein structure prediction· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1

Frequent Co-Authors

T. M. Tomasiak· 3 shared C. R. Millan· 2 shared D. A. Agard· 1 shared D. Diwanji· 1 shared D. Williams· 1 shared F. Wang· 1 shared H. Mchaourab· 1 shared J. Faraldo-Gomez· 1 shared

Activity by Year

2020-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiochemistry

T. M. Tomasiak

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The structural basis for regulation of the glutathione transporter Ycf1 by regulatory domain phosphorylation

N. K. Khandelwal, C. R. Millan, S. I. Zangari, S. Avila, D. Williams, T. M. Thaker, T. M. Tomasiak

This study presents cryo-EM structures of Ycf1 showing how phosphorylation of the regulatory domain modulates its interaction with NBD1 and affects ATPase activity.

bioRxiv · Jun 18, 2021Biochemistry

Structures of the active HER2/HER3 receptor complex reveal dynamics at the dimerization interface induced by binding of a single ligand

D. Diwanji, R. Trenker, T. M. Thaker, F. Wang, D. A. Agard, K. A. Verba, N. Jura

This study presents cryo-EM structures of the HER2/HER3 receptor complex bound to NRG1β, revealing conformational dynamics at the dimerization interface and how mutations and therapeutics interact with this interface.

bioRxiv · May 3, 2021 · PreprintBiophysics

Cryo-EM structure of an elusive pre-transport intermediate of the multidrug transporter BmrCD reveals modes of asymmetric drug binding

T. M. Thaker, S. Mishra, W. Zhou, J. Faraldo-Gomez, H. Mchaourab, T. M. Tomasiak

Cryo-EM and EPR analysis reveal cooperative substrate binding in BmrCD in an architecture primed for transport.

bioRxiv · Mar 13, 2021 · PreprintBiophysics

The peptide sensor motif stabilizes the outward-facing conformation of TmrAB

C. R. Millan, M. Francis, V. F. Thompson, T. M. Thaker, T. M. Tomasiak

This study investigates how the peptide sensor motif in TmrAB coordinates conformational changes during ATP-dependent transport, showing it stabilizes the outward-facing state.

bioRxiv · Jan 12, 2020 · PreprintBiochemistry