Targeting the endolysosomal host-SARS-CoV-2 interface by clinically licensed functional inhibitors of acid sphingomyelinase (FIASMA) including the antidepressant fluoxetine
S. Schloer, L. Brunotte, J. Goretzko, A. Mecate-Zambrano, N. Korthals, V. Gerke, S. Ludwig, U. Rescher
This study identifies fluoxetine and other FIASMAs as inhibitors of SARS-CoV-2 entry by targeting endolysosomal acidification and cholesterol accumulation.
bioRxiv · Jul 27, 2020Microbiology