Author

U. Rescher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Cell Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

J. Goretzko· 3 shared S. Schloer· 3 shared A. Mecate-Zambrano· 2 shared L. Brunotte· 2 shared S. Ludwig· 2 shared V. Gerke· 2 shared A. L. Linard Matos· 1 shared C. A. Raabe· 1 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersImmunology

J. Goretzko

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Comparative analysis of Formyl peptide receptor 1 and Formyl peptide receptor 2 reveals shared and preserved signaling profiles

U. Rescher, C. A. Raabe, D. Pajonczyk, M. F. Sternschulte, M. Bermudez, O. Soehnlein

The paper compares FPR1 and FPR2 signaling profiles using agonists, finding shared core signatures and low activity ratios for FPR2 agonists, challenging assumptions about receptor-specific inflammatory profiles.

bioRxiv · Feb 8, 2024 · PreprintPharmacology & Toxicology

Leukocyte adhesion is governed by endolysosomal two pore channel 2 (TPC2)

J. Goretzko, N. Heitzig, K. Thomas, E. K. Krogsaeter, J. Nass, A. L. Linard Matos, T. Wegner, S. Schloer, V. Gerke, J. Rossaint, F. Glorius, F. Bracher, C. M. Grimm, U. Rescher

The paper shows that TPC2 regulates endothelial cell surface P-selectin by controlling CD63 transfer from endosomes to Weibel-Palade bodies, affecting leukocyte recruitment during inflammation.

bioRxiv · Sep 28, 2021 · PreprintImmunology

Conserved cholesterol-related activities of Dispatched drive Sonic hedgehog shedding from the cell membrane

K. Grobe, K. Ehring, D. Manikowski, J. Froese, P. Jakobs, F. Gude, U. Rescher, J. Goretzko

This study shows that Dispatched (Disp) facilitates cholesterol-dependent ectodomain shedding of Sonic hedgehog (Shh) ligand, and that this process is rescued by cholesterol removal or overexpression of Disp or Patched.

bioRxiv · Oct 19, 2020Cell Biology

Drug synergy of combinatory treatment with remdesivir and the repurposed drugs fluoxetine and itraconazole effectively impairs SARS-CoV-2 infection in vitro

U. Rescher, S. Schloer, L. Brunotte, A. Mecate-Zambrano, S. Zheng, J. Tang, S. Ludwig

This study evaluates the antiviral effects of combining remdesivir with repurposed drugs fluoxetine and itraconazole, showing >90% inhibition of SARS-CoV-2 particle production in vitro.

bioRxiv · Oct 16, 2020Pharmacology & Toxicology

Targeting the endolysosomal host-SARS-CoV-2 interface by clinically licensed functional inhibitors of acid sphingomyelinase (FIASMA) including the antidepressant fluoxetine

S. Schloer, L. Brunotte, J. Goretzko, A. Mecate-Zambrano, N. Korthals, V. Gerke, S. Ludwig, U. Rescher

This study identifies fluoxetine and other FIASMAs as inhibitors of SARS-CoV-2 entry by targeting endolysosomal acidification and cholesterol accumulation.

bioRxiv · Jul 27, 2020Microbiology