Activation mechanism of Small Heat Shock Protein HSPB5 revealed by disease-associated mutants.
C. N. Woods, M. K. Janowska, L. D. Ulmer, J. K. Sidhu, N. L. Stone, E. I. James, M. Guttman, M. F. Bush, R. E. Klevit
This study investigates the activation mechanism of HSPB5 by comparing wild-type and disease-associated mutants, revealing that mutations cause constitutive activation and increased co-aggregation propensity.
bioRxiv · May 30, 2022Biophysics