Author

M. F. Bush

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1 Assay:metabolomics· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

A. Martynova· 1 shared A. Nath· 1 shared B. J. Werth· 1 shared B. P. Zercher· 1 shared C. N. Woods· 1 shared D. Canzani· 1 shared D. H. Ross· 1 shared D.-V. Rusnac· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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1 shared paperPharmacology & Toxicology

A. Martynova

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

An artificial intelligence accelerated virtual screening platform for drug discovery

G. Zhou, D.-V. Rusnac, H. Park, D. Canzani, H. M. Nguyen, L. Stewart, M. F. Bush, P. T. Nguyen, H. Wulff, V. Yarov-Yarovoy, N. Zheng, F. DiMaio

The paper develops RosettaVS, an AI-accelerated virtual screening platform that identifies drug candidates with high binding affinity across two targets, achieving a 14% and 44% hit rate in under seven days.

bioRxiv · Mar 28, 2024Biochemistry

Drugs Form Ternary Complexes with Human Liver Fatty Acid Binding Protein (FABP1) and FABP1 Binding Alters Drug Metabolism

K. C. B. Yabut, A. Martynova, A. Nath, B. P. Zercher, M. F. Bush, N. Isoherranen

This study shows drugs form ternary complexes with human FABP1 and that FABP1 binding alters drug metabolism by affecting CYP2C9 activity.

bioRxiv · Jan 17, 2024Pharmacology & Toxicology

Elucidating the Impact of Bacterial Lipases, Human Serum Albumin, and FASII Inhibition on the Utilization of Exogenous Fatty Acids by Staphylococcus aureus

E. L. Pruitt, R. Zhang, D. H. Ross, N. K. Ashford, X. Chen, F. Alonzo, M. F. Bush, B. J. Werth, L. Xu

This study investigates how Staphylococcus aureus utilizes exogenous fatty acids through lipases, human serum albumin, and FASII inhibition, showing effects on lipid composition, membrane fluidity, and antimicrobial susceptibility.

bioRxiv · Jun 29, 2023 · PreprintMicrobiology

Activation mechanism of Small Heat Shock Protein HSPB5 revealed by disease-associated mutants.

C. N. Woods, M. K. Janowska, L. D. Ulmer, J. K. Sidhu, N. L. Stone, E. I. James, M. Guttman, M. F. Bush, R. E. Klevit

This study investigates the activation mechanism of HSPB5 by comparing wild-type and disease-associated mutants, revealing that mutations cause constitutive activation and increased co-aggregation propensity.

bioRxiv · May 30, 2022Biophysics