R. E. Klevit

The intrinsically disordered N-terminus of SUMO1 is an intramolecular inhibitor of SUMO1 interactions

The paper identifies the intrinsically disordered N-terminus of SUMO1 as an intramolecular inhibitor of SUMO-SIM interactions, revealing a mechanism of disorder-based autoinhibition.

BRCA1/BARD1 intrinsically disordered regions facilitate chromatin recruitment and ubiquitylation.

This study identifies intrinsically disordered regions in BRCA1/BARD1 that mediate chromatin recruitment and ubiquitylation, enhancing DNA damage repair and transcriptional regulation.

Activation mechanism of Small Heat Shock Protein HSPB5 revealed by disease-associated mutants.

This study investigates the activation mechanism of HSPB5 by comparing wild-type and disease-associated mutants, revealing that mutations cause constitutive activation and increased co-aggregation propensity.

A native chemical chaperone in the human eye lens

This study identifies myo-inositol as a chemical chaperone that suppresses lens crystallin aggregation, suggesting its potential as a therapeutic target for age-related cataracts.

Interplay of disordered and ordered regions of a human small heat shock protein yields an ensemble of \"quasi-ordered\" states.

This study characterizes the disordered N-terminal region of HSPB1 using hybrid methods, revealing quasi-ordered states and their role in HSPB1 function and disease.

Indirect sexual selection drives rapid sperm protein evolution

The paper shows that FITZAP, a sperm protein in abalone, coevolves with lysin to maintain binding despite rapid changes in the lysin-VERL interface, driven by sexual selection.

Solution structure of sperm lysin yields novel insights into molecular dynamics of rapid protein evolution

This study presents the solution structure of sperm lysin from red abalone and identifies a VERL binding interface shaped by positive selection and structural flexibility.