Author

E. I. James

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:machine learning (classical)· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

M. Guttman· 2 shared A. Nath· 1 shared C. N. Woods· 1 shared D. W. Baggett· 1 shared E. Chang· 1 shared J. K. Sidhu· 1 shared J. Schachter· 1 shared K. Choi· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

M. Guttman

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2 papers

Recent·Most cited

Tryptanthrin Analogs Substoichiometrically Inhibit Seeded and Unseeded Tau4RD Aggregation

E. I. James, D. W. Baggett, E. Chang, J. Schachter, T. Nixey, K. Choi, M. Guttman, A. Nath

The paper identifies tryptanthrin analogs as potent substoichiometric inhibitors of tau4RD aggregation, showing low nanomolar potency and demonstrating structure-activity relationship principles for tau targeting.

bioRxiv · Feb 2, 2024 · PreprintBiochemistry

Activation mechanism of Small Heat Shock Protein HSPB5 revealed by disease-associated mutants.

C. N. Woods, M. K. Janowska, L. D. Ulmer, J. K. Sidhu, N. L. Stone, E. I. James, M. Guttman, M. F. Bush, R. E. Klevit

This study investigates the activation mechanism of HSPB5 by comparing wild-type and disease-associated mutants, revealing that mutations cause constitutive activation and increased co-aggregation propensity.

bioRxiv · May 30, 2022Biophysics