M. Guttman

Structure of a human monoclonal antibody in complex with Outer surface protein C (OspC) of the Lyme disease spirochete, Borreliella burgdorferi

This study determines the structure of a human monoclonal antibody in complex with OspC from Borreliella burgdorferi, revealing its epitope and interaction mechanism.

Tryptanthrin Analogs Substoichiometrically Inhibit Seeded and Unseeded Tau4RD Aggregation

The paper identifies tryptanthrin analogs as potent substoichiometric inhibitors of tau4RD aggregation, showing low nanomolar potency and demonstrating structure-activity relationship principles for tau targeting.

The genomic and cellular basis of biosynthetic innovation in rove beetles

This study investigates the genomic and cellular basis of biosynthetic innovation in rove beetles, identifying key genomic and cellular mechanisms underlying the evolution of defensive secretions.

Combinatorial immune refocusing within the influenza hemagglutinin head elicits cross-neutralizing antibody responses

This study evaluates trihead nanoparticle immunogens to enhance cross-neutralizing antibody responses against influenza H1 viruses by combining immunofocusing techniques.

Activation mechanism of Small Heat Shock Protein HSPB5 revealed by disease-associated mutants.

This study investigates the activation mechanism of HSPB5 by comparing wild-type and disease-associated mutants, revealing that mutations cause constitutive activation and increased co-aggregation propensity.

Profiling of the drug resistance of thousands of Src tyrosine kinase mutants uncovers a regulatory network that couples autoinhibition to catalytic domain dynamics

Integrative Genome Modeling Platform reveals essentialityof rare contact events in 3D genome organizations

The paper develops a multi-modal data integration approach to improve genome structure modeling and shows that rare contact events are essential for predicting nuclear architecture.

Xist-seeded nucleation sites form local concentration gradients of silencing proteins to inactivate the X-chromosome

This study identifies Xist-seeded nucleation sites that create local concentration gradients of silencing proteins, leading to X-chromosome inactivation through macromolecular crowding.

Elicitation of potent neutralizing antibody responses by designed protein nanoparticle vaccines for SARS-CoV-2

This study designs SARS-CoV-2 nanoparticle vaccines that induce strong neutralizing antibodies in mice, with higher titers and lower doses than existing trimer vaccines.

Elicitation of broadly protective immunity to influenza by multivalent hemagglutinin nanoparticle vaccines

Nanoparticle immunogens with four seasonal influenza hemagglutinins elicit neutralizing antibodies against both the head and stem, providing broad protection against diverse influenza strains.

Interplay of disordered and ordered regions of a human small heat shock protein yields an ensemble of \"quasi-ordered\" states.

This study characterizes the disordered N-terminal region of HSPB1 using hybrid methods, revealing quasi-ordered states and their role in HSPB1 function and disease.