Evolutionary BiologybioRxiv
HIV-1 Vif gained breadth in APOBEC3G specificity after cross-species transmission of its precursors
The paper explores how HIV-1 Vif evolved to broaden its specificity for APOBEC3G through cross-species transmission, revealing Loop 5 adaptations that enhance its ability to antagonize A3G variants.
DOI 10.1128/jvi.02071-21