Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
12 papers
Recent·Most cited
S. Speaks, A. Zani, A. Solstad, A. Kenney, M. McFadden, L. Zhang, A. C. Eddy, A. O. Amer, R. Robinson, C. Cai, J. Ma, E. Hemann, A. Forero, J. Yount
This study shows that gasdermin D promotes influenza virus-induced mortality by amplifying neutrophil-driven inflammation.
bioRxiv · Mar 8, 2023Immunology
M. M. Shamseldin, A. Zani, A. Kenney, J. Evans, C. Zeng, K. A. Read, K. Caution, J. M. Hall, J. M. Brown, G. Gunsch, K. N. Corps, S. Chaitwatponsakom, M. KC, M. Lu, R. Deora, , P. Dubey
bioRxiv · Apr 6, 2022 · PreprintImmunology
E. Kudryashova, A. Zani, G. Vilmen, A. Sharma, W. Lu, J. S. Yount, D. S. Kudryashov
This study shows that human defensins HNP1 and RC-101 destabilize SARS-CoV-2 Spike protein and inhibit viral infection in cell culture.
Journal of Molecular Biology · Mar 1, 2022Peer-reviewedImmunology
A. Zani, A. Kenney, J. Kawahara, A. C. Eddy, X.-L. Wang, M. KC, M. Lu, E. A. Hemann, J. Li, M. E. Peeples, L. Hall-Stoodley, A. Forero, C. Cai, J. Ma, J. S. Yount
This study shows that IFITM3 protects mice from severe SARS-CoV-2 infection by limiting viral spread and inflammation, as demonstrated through knockout mouse models.
bioRxiv · Dec 22, 2021 · PreprintImmunology
S. Miersch, R. Saberianfar, C. Chen, N. Sharma, G. K. Amarasinghe, F. Caccuri, A. Zani, A. Caruso, G. Novelli, S. S. Sidhu
This study develops a tetravalent antibody format that neutralizes SARS-CoV-2 variants with high potency and breadth, surpassing conventional bivalent antibodies.
bioRxiv · Nov 2, 2021Bioengineering
A. D. Kenney, S. L. Aron, C. Gilbert, N. Kumar, P. Chen, A. Eddy, L. Zhang, A. Zani, N. Vargas-Maldonado, S. Speaks, J. Kawahara, P. J. Denz, L. Dorn, F. Accornero, J. Ma, , J. S. Yount
This study shows that influenza virus directly infects cardiomyocytes, causing heart dysfunction and fibrosis, challenging the prevailing model of indirect cardiotoxicity.
bioRxiv · Oct 27, 2021Immunology
M. Eltobgy, A. Zani, A. Kenney, S. Estfanous, E. Kim, A. Badr, C. Carafice, K. Daily, O. Whitham, M. Pietrzak, A. Webb, J. Kawahara, A. Eddy, P. Denz, M. Lu, , A. Amer
This study shows that caspase-4/11 worsens SARS-CoV-2 infection by increasing inflammation and thrombosis, independent of GSDMD, suggesting it as a potential drug target for severe COVID-19.
bioRxiv · Sep 24, 2021Immunology
G. Shi, A. I. Chiramel, K. K. Lai, A. Kenney, T. Li, T. Dempsey, A. Zani, L. Zhang, S. Majdoul, S. Das, P. A. Beare, S. Kar, T. Andresson, S. M. Best, J. S. Yount, A. A. Compton
This study shows rapalogs like rapamycin increase SARS-CoV-2 infection by reducing antiviral proteins through microautophagy, while ridaforolimus has less effect.
bioRxiv · Apr 15, 2021Microbiology
M. Chemudupati, A. Smith, R. Fillinger, A. Kenney, L. Zhang, A. Zani, S.-L. Liu, M. Z. Anderson, A. Sharma, J. Yount
This study shows butyrate promotes virus infection by repressing interferon stimulated genes without disrupting IFN signaling.
bioRxiv · Feb 4, 2020 · PreprintMicrobiology
A. Kenney, T. M. McMichael, A. Imas, N. M. Chesarino, L. Zhang, L. E. Dorn, Q. Wu, O. Alfaour, F. Amari, M. Chen, A. Zani, M. Chemudupati, F. Accornero, V. Coppola, M. V. S. Rajaram, J. S. Yount
This study shows that IFITM3 deficiency in mice worsens influenza virus-induced cardiac dysfunction, revealing its protective role in the heart during infection.
bioRxiv · Jan 11, 2019Immunology
T. M. McMichael, Y. Zhang, A. D. Kenney, L. Zhang, A. Zani, M. Lu, M. Chemudupati, J. Li, J. S. Yount
This study identifies IFITM3 and TLR7 as endosomal factors that differentially regulate hMPV infection, with IFITM3 restricting it and TLR7 enhancing it in some strains.
bioRxiv · Jun 7, 2018Immunology