J. S. Yount

Innate immune control of influenza virus interspecies adaptation

This study shows that IFITM3 deficiency in mice allows avian influenza viruses to infect and adapt more effectively, suggesting a role for IFITM3 in preventing zoonotic virus emergence.

Aiolos modulates the TFH and CD4-CTL differentiation programs via reciprocal regulation of the Zfp831/TCF-1/Bcl-6 axis and CD25

This study identifies Aiolos as a regulator of TFH and CD4-CTL differentiation, showing it modulates the Zfp831/TCF-1/Bcl-6 axis and suppresses the cytotoxic gene program.

Prime-pull immunization of mice with a BcfA-adjuvanted vaccine elicits mucosal immunity and prevents SARS CoV-2 infection and pathology

SARS-CoV-2 inactivation by human defensin HNP1 and retrocyclin RC-101

This study shows that human defensins HNP1 and RC-101 destabilize SARS-CoV-2 Spike protein and inhibit viral infection in cell culture.

Interferon-induced transmembrane protein 3 (IFITM3) limits lethality of SARS-CoV-2 in mice

This study shows that IFITM3 protects mice from severe SARS-CoV-2 infection by limiting viral spread and inflammation, as demonstrated through knockout mouse models.

Influenza virus replication in cardiomyocytes drives heart dysfunction and fibrosis

This study shows that influenza virus directly infects cardiomyocytes, causing heart dysfunction and fibrosis, challenging the prevailing model of indirect cardiotoxicity.

Overexpression of the SETD2 WW domain inhibits the phosphor-IWS1/SETD2 interaction and the oncogenic AKT/IWS1 RNA splicing program.

The paper was withdrawn due to concerns about the integrity of the reported results on alternative splicing of U2AF2.

SARS-CoV-2 Nsp14 activates NF-κB signaling and induces IL-8 upregulation

This study shows that SARS-CoV-2 Nsp14 activates NF-κB signaling and increases IL-8 expression, which is confirmed in infected cells and lung tissue from COVID-19 patients.

A bioorthogonal chemical reporter for fatty acid synthase-dependent protein acylation

This study introduces a bioorthogonal chemical reporter, Alk-4, to selectively label and study FASN-dependent protein acylation in cells and viruses.

Rapalogs downmodulate intrinsic immunity and promote cell entry of SARS-CoV-2

This study shows rapalogs like rapamycin increase SARS-CoV-2 infection by reducing antiviral proteins through microautophagy, while ridaforolimus has less effect.

Moderately pathogenic maternal influenza A virus infection disrupts placental integrity but spares the fetal brain

This study shows that moderate maternal influenza A virus infection causes placental issues but not fetal brain inflammation in mice.

IWS1 phosphorylation by AKT3 controls nuclear export of type I IFN mRNAs and sensitivity to oncolytic viral infection, by regulating the alternative RNA splicing of U2AF2.

The paper was withdrawn due to concerns about the validity of the reported alternative splicing mechanism of U2AF2 and potential data manipulation.

Opposing activities of IFITM proteins in SARS-CoV-2 infection

This study identifies opposing roles of IFITM3 in restricting and enhancing SARS-CoV-2 infection through distinct mechanisms involving endosomal restriction and plasma membrane fusion.

IFITMs Inhibit Cell Fusion Mediated by Trophoblast Syncytins

This study shows that IFITMs inhibit trophoblast cell fusion and enhance antiviral resistance in BeWo cells.

IFITM3 protects the heart during influenza virus infection

This study shows that IFITM3 deficiency in mice worsens influenza virus-induced cardiac dysfunction, revealing its protective role in the heart during infection.

IFITM3 restricts human metapneumovirus infection

This study identifies IFITM3 and TLR7 as endosomal factors that differentially regulate hMPV infection, with IFITM3 restricting it and TLR7 enhancing it in some strains.