PathologybioRxiv
The mechanical regulation of RNA binding protein hnRNPC in the failing heart
F. Martino, N. M. Varadarajan, A. R. Perestrelo…·G. Forte
The paper shows that hnRNPC upregulation and relocation to the Z-disk in failing hearts affects mRNA alternative splicing and mechanotransduction.
DOI 10.1126/scitranslmed.abo5715