The human immune checkpoint molecule, HLA-G2, induces tolerance in monocytes and dendritic cells via upregulation of PD-L1
A. Takahashi, K. Kuroki, N. Maeda, M. Nieda, K. Maenaka
This paper shows HLA-G2 induces tolerance in human monocytes and dendritic cells by upregulating PD-L1 through LILRB2 binding, suggesting it as a target for immune checkpoint therapy.
bioRxiv · Oct 14, 2023 · PreprintImmunology