Author

A. Matsuda

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Cell Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Assay:imaging· 2 Approach:microscopy & imaging analysis· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Czarna· 3 shared G. Dubin· 3 shared K. Pyrc· 3 shared M. Pachota· 3 shared A. Karim· 2 shared A. Mourao· 2 shared G. Popowicz· 2 shared J. Plewka· 2 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersMicrobiology

A. Czarna

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

2-Thiouridine is a broad-spectrum antiviral nucleoside analogue against positive-strand RNA viruses

K. Uemura, H. Nobori, A. Sato, S. Toba, S. Kusakabe, M. Sasaki, K. Tabata, K. Matsuno, N. Maeda, S. Ito, M. Tanaka, Y. Anraku, S. Kita, M. Ishii, K. Kanamitsu, , K. Maenaka

This study identifies 2-thiouridine as a broad-spectrum antiviral against SARS-CoV-2 and other positive-strand RNA viruses by inhibiting viral RNA synthesis.

bioRxiv · Dec 14, 2022Microbiology

Refolding of lid subdomain of SARS-CoV-2 nsp14 upon nsp10 interaction releases exonuclease activity.

A. Czarna, J. Plewka, L. Kresik, A. Matsuda, A. Karim, C. Robinson, S. O Byrne, F. Cunningham, I. Georgiou, M. Pachota, G. Popowicz, P. G. Wyatt, G. Dubin, K. Pyrc

The paper presents the crystal structure of SARS-CoV-2 nsp14 in apo-form and explains how nsp10 modulates its exonuclease activity through structural changes.

Structure · Aug 1, 2022Peer-reviewedMicrobiology

Despite the odds: formation of the SARS-CoV-2 methylation complex.

A. Matsuda, J. Plewka, Y. Chykunova, A. N. Jones, M. Pachota, M. Rawski, A. Mourao, A. Karim, L. Kresik, K. Lis, I. Minia, K. Hartman, R. Sonani, G. Dubin, M. Sattler, , A. Czarna

This study demonstrates that SARS-CoV-2 proteins nsp14, nsp10, and nsp16 form a heterotrimer complex, which modulates nsp14's exonuclease activity and protects viral RNA.

bioRxiv · Jan 25, 2022Microbiology

Acriflavine, a clinically aproved drug, inhibits SARS-CoV-2 and other betacoronaviruses

V. Napolitano, A. Dabrowska, K. Schorpp, A. Mourao, E. Barreto-Duran, M. Benedyk, P. Botwina, S. Brandner, M. Bostock, Y. Chykunova, A. Czarna, G. Dubin, T. Frohlich, M. Hoelscher, M. Jedrysik, , K. Pyrc

This study identifies acriflavine as a potent inhibitor of SARS-CoV-2 and other betacoronaviruses, effective in cellular models, in vivo, and ex vivo.

bioRxiv · Mar 20, 2021Microbiology

A multi-hierarchical approach reveals D-serine as a hidden substrate of sodium-coupled monocarboxylate transporters

P. Wiriyasermkul, S. Moriyama, M. Suzuki, P. Kongpracha, N. Nakamae, S. Takeshita, Y. Tanaka, A. Matsuda, M. Miyasaka, K. Hamase, T. Kimura, M. Mita, J. Sasabe, S. Nagamori

The paper identifies two renal D-serine transport systems, revealing ASCT2 as a noncanonical substrate of SMCTs and highlighting their physiological and pathological roles.

bioRxiv · Aug 10, 2020Biochemistry

The Linear Element is a Stable Structure Along the Chromosome Axis in Fission Yeast

D.-Q. Ding, A. Matsuda, K. Okamasa, Y. Hiraoka

This study uses live cell imaging to characterize the stable structure and dynamics of LinEs in fission yeast during meiosis.

bioRxiv · Jul 3, 2020 · PreprintCell Biology

Asymmetrical localization of Nup107-160 subcomplex components within the nuclear pore complex in fission yeast

H. Asakawa, T. Kojidani, H.-J. Yang, C. Ohtsuki, H. Osakada, A. Matsuda, M. Iwamoto, Y. Chikashige, K. Nagao, C. Obuse, Y. Hiraoka, T. Haraguchi

This study reveals asymmetrical localization of the Nup107-160 subcomplex in fission yeast, contrasting with symmetrical localization in other organisms, and shows its necessity for cell cycle progression.

bioRxiv · Feb 28, 2019Cell Biology