A nanobody that recognizes a 14-residue peptide epitope in the E2 ubiquitin-conjugating enzyme UBC6e modulates its activity
J. Ling, R. W. Cheloha, N. McCaul, Z.-Y. J. Sun, G. Wagner, H. L. Ploegh
The paper identifies a nanobody that binds to a 14-residue epitope on UBC6e, enhancing its enzymatic activity and inhibiting phosphorylation in response to cell stress.
bioRxiv · Jul 13, 2019Biochemistry