Author

H. L. Ploegh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Biochemistry· 2 Bioengineering· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 4 Assay:proteomics· 4 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Assay:protein structure· 2

Frequent Co-Authors

F. I. Schmidt· 2 shared J. Ling· 2 shared L. D. J. Schiffelers· 2 shared M. Geyer· 2 shared R. W. Cheloha· 2 shared S. Normann· 2 shared A. Alon· 1 shared A. Anastas· 1 shared

Activity by Year

2017-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersImmunology

F. I. Schmidt

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Nanobody-targeted conditional antimicrobial therapeutics

C. Ngambenjawong, H. Ko, N. Pishesha, H. L. Ploegh, S. N. Bhatia

This study designs nanobody-targeted conditional antimicrobial therapeutics to deliver therapeutic cargos to bacterial infection sites by enhancing protease activation through proximity-enabled reactivity.

ACS Nano · Mar 5, 2025Peer-reviewedBioengineering

ESAT-6 undergoes self-association at phagosomal pH and an ESAT-6 specific nanobody restricts M. tuberculosis growth in macrophages

T. A. Bates, M. Trank-Greene, X. Nguyenla, A. Anastas, S. Gurmessa, I. R. Merutka, S. D. Dixon, A. Shumate, A. R. Groncki, M. A. Parson, J. R. Ingram, E. Barklis, J. E. Burke, U. Shinde, H. L. Ploegh, F. G. Tafesse

This study investigates ESAT-6's self-association under acidic conditions and shows an ESAT-6-specific nanobody inhibits M. tuberculosis growth in macrophages.

bioRxiv · Aug 16, 2023Biochemistry

Antagonistic nanobodies reveal mechanism of GSDMD pore formation and unexpected therapeutic potential

L. D. J. Schiffelers, S. Normann, S. C. Binder, E. Hagelauer, A. Kopp, A. Alon, M. Geyer, H. L. Ploegh, F. I. Schmidt

This study uses nanobodies to reveal GSDMD pore formation mechanism and shows their therapeutic potential in preventing pyroptosis.

bioRxiv · Apr 20, 2023Immunology

P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection

L.-M. Jenster, K.-E. Lange, S. Normann, A. vom Hemdt, J. D. Wuerth, L. D. J. Schiffelers, Y. M. Tesfamariam, F. N. Gohr, L. Klein, I. H. Kaltheuner, D. J. Lapp, J. Mayer, J. Moecking, H. L. Ploegh, E. Latz, , F. I. Schmidt

This study identifies p38 kinases as a central signaling hub for NLRP1 inflammasome activation in response to ribotoxic stress and virus infection.

bioRxiv · Jan 24, 2022Immunology

Antigen-specific induction of CD4+CD8αα+ intraepithelial T lymphocytes byBacteroidetes species

D. Bousbaine, P. Bhagchandani, M. London, M. Mimee, S. Olesen, M. Poyet, R. W. Cheloha, J. Sidney, J. Ling, A. Gupta, T. K. Lu, A. Sette, E. J. Alm, D. Mucida, A. M. Bilate, H. L. Ploegh

This study identifies Bacteroidetes species that induce CD4+CD8αα+ intraepithelial T lymphocytes, which provide protective immunity against colitis.

bioRxiv · Aug 5, 2020 · PreprintImmunology

A nanobody that recognizes a 14-residue peptide epitope in the E2 ubiquitin-conjugating enzyme UBC6e modulates its activity

J. Ling, R. W. Cheloha, N. McCaul, Z.-Y. J. Sun, G. Wagner, H. L. Ploegh

The paper identifies a nanobody that binds to a 14-residue epitope on UBC6e, enhancing its enzymatic activity and inhibiting phosphorylation in response to cell stress.

bioRxiv · Jul 13, 2019Biochemistry

Chaperone AMPylation modulates aggregation and toxicity of neurodegenerative disease-associated polypeptides

M. C. Truttmann, D. Pincus, H. L. Ploegh

This study shows that AMPylation of HSP70 modulates protein aggregation and toxicity in neurodegenerative disease models using C. elegans.

bioRxiv · Sep 1, 2017Cell Biology