Evolution of an enzyme conformational ensemble guides design of an efficient biocatalyst
A. Broom, R. V. Rakotoharisoa, M. C. Thompson, N. Zarifi, E. Nguyen, N. Mukhametzhanov, L. Liu, J. S. Fraser, R. A. Chica
The paper uses X-ray crystallography to study conformational changes in an evolved enzyme, leading to the design of a more efficient biocatalyst by focusing on active-site mutations.
bioRxiv · Mar 19, 2020Biophysics