Single cell RNA sequencing reveals mechanisms underlying a senescence-like phenotype of Alveolar Macrophages during Aging
Y. Wu, B. Zhu, R. Zhang, N. P. Goplen, X. Gao, H. Narasimhan, A. Shi, Y. Chen, Y. Li, H. Dong, T. J. Braciale, J. Sun
This study uses single-cell RNA sequencing to show that aged alveolar macrophages exhibit a senescence-like phenotype linked to reduced CBFβ expression and impaired self-renewal.
bioRxiv · Jun 4, 2022 · PreprintImmunology