Surface-modified measles vaccines encoding oligomeric, fusion-stabilized SARS-CoV-2 spike glycoproteins bypass measles seropositivity, boosting neutralizing antibody responses to omicron and historical variants.
M. A. Munoz Alia, R. A. Nace, B. Balakrishnan, L. Zhang, N. Packiriswamy, G. Singh, P. Warang, I. Mena, R. Narjari, R. Vandergaast, A. Garcia-Sastre, M. Schotsaert, S. J. Russell
This study develops a measles-based vaccine encoding SARS-CoV-2 spike glycoproteins that enhances neutralizing antibody responses against both omicron and historical variants.
bioRxiv · Dec 16, 2022Microbiology