Author

C. Ziegler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Microbiology· 3 Biochemistry· 2 Immunology· 2 Cell Biology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:human· 4 Approach:statistical model· 4 Organism:bacteria (other)· 3 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 3 Assay:structural biology· 2

Frequent Co-Authors

L. R. Forrest· 3 shared V. Heinz· 3 shared V. Leone· 3 shared A. Baum· 2 shared C. A. Kyratsous· 2 shared C. Gnanadurai· 2 shared C. Koshy· 2 shared J. Recker· 2 shared

Activity by Year

2018-2022 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersBiophysics

L. R. Forrest

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Author profile →

12 papers

Recent·Most cited

Autoregulation of a trimeric transporter involves the cytoplasmic domains of both adjacent subunits

V. Leone, R. T. Bradshaw, C. Koshy, P. S. Lee, C. Fenollar-Ferrer, V. Heinz, C. Ziegler, L. R. Forrest

This study uses molecular simulations to analyze the autoregulatory domains of BetP, showing how C-terminal tails interact with neighboring subunits and how N-terminal tails may also contribute to regulation.

bioRxiv · Jun 5, 2022Biochemistry

Osmotic stress response in BetP: How lipids and K+ team up to overcome downregulation

V. Heinz, G. Gueler, V. Leone, M. G. Madej, S. Maksimov, R. M. Gaertner, O. Rudi, F. Hamdi, P. L. Kastritis, W. Maentele, R. Kraemer, L. R. Forrest, C. Perez, C. Ziegler

This study investigates how K+ and lipids regulate BetP's osmotic stress response by analyzing structural changes and K+ interactions in BetP.

bioRxiv · Jun 2, 2022 · PreprintBiophysics

VanRS and CroRS cross-talk revealed by coevolutionary modeling regulates antibiotic resistance in VanA-type vancomycin-resistant Enterococcus faecalis

X.-L. Jiang, U. T. Nguyen, C. Ziegler, D. Goel, K. Palmer, F. Morcos

The paper identifies cross-talk between horizontally acquired and endogenous two-component systems in VanA-type vancomycin-resistant Enterococcus faecalis that contributes to antibiotic synergy.

bioRxiv · May 5, 2022 · PreprintMicrobiology

The structure of HiSiaQM defines the architecture of tripartite ATP-independent periplasmic (TRAP) transporters

M. F. Peter, P. Depping, N. Schneberger, E. Severi, K. Gatterdam, S. Tindall, A. Durand, V. Heinz, P. A. Koenig, M. Geyer, C. Ziegler, G. H. Thomas, G. Hagelueken

This paper presents the first cryo-EM structure of TRAP transporter membrane domains and identifies structural features that enable monomeric elevator architecture.

bioRxiv · Dec 3, 2021Biochemistry

Boosting of SARS-CoV-2 immunity in nonhuman primates using an oral rhabdoviral vaccine

K. W. Peng, T. Carey, P. Lech, R. Vandergaast, M. A. Munoz-Alia, N. Packiriswamy, C. Gnanadurai, K. Krotova, M. Tesfay, C. Ziegler, M. Haselton, K. Sevola, C. Lathrum, S. Reiter, R. Narjari, , S. J. Russell

This study develops an oral rhabdoviral vaccine that boosts SARS-CoV-2 immunity in nonhuman primates by enhancing viral tropism through G protein trans-complementation.

bioRxiv · Oct 16, 2021Immunology

Quantification and uncertainty of root growth stimulation by elevated CO2 in mature temperate deciduous forest

C. Ziegler, A. Kulawska, A. Kourmouli, L. Hamilton, Z. Shi, R. MacKenzie, R. Dyson, I. Johnston

The paper quantifies root growth stimulation by elevated CO2 in a mature temperate deciduous forest and assesses associated uncertainties.

bioRxiv · Apr 15, 2021Plant Biology

Aggregated Mycobacterium tuberculosis enhances the inflammatory response

A. Sigal, H. Rodel, I. M. Ferreira, C. Ziegler, Y. Ganga, M. Bernstein, S.-H. Hwa, G. Kaplan, G. Lustig, K. Nargan, M. Noursadeghi, A. Steyn, A. K. Shalek

The paper investigates how aggregated Mycobacterium tuberculosis triggers a stronger inflammatory response in macrophages compared to single or multiple non-aggregated bacilli.

bioRxiv · Mar 23, 2021Microbiology

GRK2/3/5/6 knockout: The impact of individual GRKs on arrestin-binding and GPCR regulation

J. Drube, R. S. Haider, E. S. F. Matthees, M. Reichel, J. Zeiner, S. Fritzwanker, C. Ziegler, S. Barz, L. Klement, A. Kliewer, E. Miess, E. Kostenis, S. Schulz, C. Hoffmann

This study investigates the role of individual GRKs in GPCR regulation and β-arrestin interactions using GRK knockout cells and identifies distinct GRK-mediated mechanisms.

bioRxiv · Feb 12, 2021Cell Biology

CopR, a global regulator of transcription to maintain copper homeostasis in Pyrococcus furiosus

F. Gruenberger, R. Reichelt, I. Waege, V. Ned, K. Bronner, M. Kaljanac, N. Weber, Z. El-Ahmad, L. Knauss, M. G. Madej, C. Ziegler, D. Grohmann, W. Hausner

The paper identifies CopR as a global regulator essential for copper homeostasis in Pyrococcus furiosus by analyzing transcriptome and genome-wide binding data.

bioRxiv · Aug 14, 2020Microbiology

Development and validation of IMMUNO-COV: a high-throughput clinical assay for detecting antibodies that neutralize SARS-CoV-2

R. Vandergaast, T. Carey, S. Reiter, P. Lech, C. Gnanadurai, M. Tesfay, J. Buehler, L. Suksanpaisan, S. Naik, B. Brunton, J. Recker, M. Haselton, C. Ziegler, A. Roesler, J. R. Mills, , S. J. Russell

The paper develops and validates IMMUNO-COV, a high-throughput assay that accurately quantifies SARS-CoV-2-neutralizing antibodies in human sera.

bioRxiv · May 26, 2020 · PreprintImmunology

FluidFM as a Tool to Study Adhesion Forces of Bacteria - Optimization of Parameters and Comparison to Conventional Bacterial Probe Scanning Force Spectroscopy

L. Hofherr, C. Müller-Renno, C. Ziegler

This study optimizes FluidFM parameters for measuring bacterial adhesion forces and shows comparable results to conventional methods using polydopamine.

bioRxiv · Dec 19, 2019Biophysics

Assignment of the resting state of the secondary active transporter BetP by integrating spectroscopic measurements and molecular simulations

V. Leone, I. Waclawska, C. Koshy, K. Kossman, M. Sharma, T. F. Prisner, C. Ziegler, B. Endeward, L. R. Forrest

The paper assigns the resting state of BetP by integrating spectroscopic measurements and molecular simulations to clarify its transport mechanism.

bioRxiv · Apr 27, 2018Biophysics