Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
9 papers
Recent·Most cited
V. Rayaprolu, B. Fulton, A. Rafique, E. Arturo, D. Williams, C. Hariharan, H. Callaway, A. Parvate, S. L. Schendel, D. Parekh, S. Hui, K. Shaffer, K. E. Pascal, E. Wloga, S. Giordano, , E. O. Saphire
The paper presents the cryoEM structure of the Inmazeb cocktail in complex with Ebola virus glycoprotein, showing how the combination prevents escape mutations better than monotherapy.
bioRxiv · Oct 11, 2022Biophysics
K. Gayvert, R. Copin, S. McKay, I. Setliff, W. K. Lim, A. Baum, C. A. Kyratsous, G. S. Atwal
The paper analyzes SARS-CoV-2 genomic diversity to identify sites under selection, showing purifying selection dominates with some diversifying pressure, particularly in the spike protein and T cell epitopes.
bioRxiv · Dec 30, 2021 · PreprintEvolutionary Biology
K. W. Peng, T. Carey, P. Lech, R. Vandergaast, M. A. Munoz-Alia, N. Packiriswamy, C. Gnanadurai, K. Krotova, M. Tesfay, C. Ziegler, M. Haselton, K. Sevola, C. Lathrum, S. Reiter, R. Narjari, , S. J. Russell
This study develops an oral rhabdoviral vaccine that boosts SARS-CoV-2 immunity in nonhuman primates by enhancing viral tropism through G protein trans-complementation.
bioRxiv · Oct 16, 2021Immunology
R. Copin, A. Baum, E. Wloga, K. E. Pascal, S. Giordano, B. O. Fulton, A. Zhou, N. Negron, K. Lanza, N. Chan, A. Coppola, J. Chiu, M. Ni, G. S. Atwal, A. Romero Hernandez, , C. A. Kyratsous
This study shows that REGEN-COV, a combination of non-competing antibodies, provides broad coverage against SARS-CoV-2 variants and prevents the emergence of new variants in clinical and preclinical settings.
bioRxiv · Mar 10, 2021 · PreprintMicrobiology
M. McAleavy, Q. Zhang, J. Xu, L. Pan, M. Wakai, P. J. Ehmann, M. F. Wipperman, T. Shavlakadze, S. C. Hamon, A. Boyapati, L. G. Morton, C. A. Kyratsous, D. J. Glass
The paper shows elevated Activin A and FLRG levels in COVID-19 patients predict severe outcomes like mechanical ventilation and mortality.
bioRxiv · Feb 4, 2021 · PreprintImmunology
P. Wang, M. S. Nair, L. Liu, S. Iketani, Y. Luo, Y. Guo, M. Wang, J. Yu, B. Zhang, P. D. Kwong, B. S. Graham, J. R. Mascola, J. Y. Chang, M. T. Yin, M. E. Sobieszczyk, , D. D. Ho
This study evaluates the neutralization resistance of SARS-CoV-2 variants B.1.1.7 and B.1.351 to monoclonal antibodies and sera, finding increased resistance in B.1.351.
bioRxiv · Jan 25, 2021 · PreprintImmunology
A. Baum, R. Copin, D. Ajithdoss, A. Zhou, K. Lanza, N. Negron, M. Ni, Y. Wei, G. S. Atwal, A. Oyejide, Y. Goez-Gazi, J. Dutton, E. Clemmons, H. M. Staples, C. Bartley, , C. A. Kyratsous
This study evaluates the efficacy of the REGN-COV2 antibody cocktail in preventing and treating SARS-CoV-2 infection in rhesus macaques and hamsters, showing reduced virus load and pathological effects.
bioRxiv · Aug 2, 2020Microbiology
R. Vandergaast, T. Carey, S. Reiter, P. Lech, C. Gnanadurai, M. Tesfay, J. Buehler, L. Suksanpaisan, S. Naik, B. Brunton, J. Recker, M. Haselton, C. Ziegler, A. Roesler, J. R. Mills, , S. J. Russell
The paper develops and validates IMMUNO-COV, a high-throughput assay that accurately quantifies SARS-CoV-2-neutralizing antibodies in human sera.
bioRxiv · May 26, 2020 · PreprintImmunology
A. D. Baik, P. T. Calafati, N. A. Aaron, A. Mehra, S. Moller-Tank, L. Miloscio, L. Wang, M. Praggastis, M. S. Birnbaum, C. Pan, S. Brydges, A. O. Mujica, P. Barbounis, N. W. Gale, N. Li, , K. D. Cygnar
This study demonstrates that targeted enzyme replacement therapy using antibody-enzyme fusion proteins improves skeletal muscle phenotypes in Pompe disease mice compared to standard enzyme replacement therapy.
bioRxiv · Apr 22, 2020 · PreprintBioengineering