PIKfyve/Fab1 is required for efficient V-ATPase and hydrolase delivery to phagosomes, phagosomal killing, and restriction of Legionella infection
C. M. Buckley, V. L. Heath, A. Gueho, C. Bosmani, P. Knobloch, P. Sikakana, N. Personnic, S. K. Dove, R. H. Michell, R. Meier, H. Hilbi, T. Soldati, R. H. Insall, J. King
This paper shows that PIKfyve is essential for delivering V-ATPase and proteases to phagosomes, enabling acidification and killing of bacteria, and protecting against Legionella infection.
bioRxiv · Jul 17, 2018Cell Biology